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Biotherapeutics Form and Function: Case Studies in Light Scattering

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Biotherapeutics Form and Function: Case Studies in Light Scattering

Webinar Description:

Laser light scattering is the foundation for several essential biophysical techniques that address key challenges in product characterization and formulation development. These include size exclusion chromatography coupled with light scattering for detailed characterization of aggregates and other populations and quantification of self-associative properties under proposed formulation conditions. This webinar will review light scattering technology and instrumentation, then present select examples illustrating how complete light scattering solutions facilitate rapid and effective development of biotherapeutic drug products.

Learning Objective Bullet Points:

  • The light scattering technologies and instrumentation relevant to biophysical characterization of biotherapeutics
  • How multi-angle light scattering couples to HPLC- or UHPLC-based size-exclusion chromatography (SEC-MALS) to characterize soluble and insoluble aggregates
  • How composition-gradient multi-angle light scattering (CG-MALS) characterizes reversible self-association to optimize formulations

Speaker Info:

Sophia Kenrick, Ph.D.

Senior Application Scientist

Wyatt Technology Corporation

Katherine Bowers, Ph.D.

Principal Scientist/Group Leader, Analytical and Formulation Development

FUJIFILM Diosynth Biotechnologies

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Cambridge Healthtech Institute

Cambridge Healthtech Institute

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